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This expectation was upheld in clinical trials for Vioxx (rofecoxib) and another such drug which never made it to the market, Prexige (lumiracoxib). Q: From the start, your lab raised a red flag about COX-2 inhibition because of its effect on a ...
Since then, other drugs in the class from Pfizer, Novartis, and Merck have been withdrawn (Bextra); have failed to be approved (Arcoxia, Prexige); or have been retained on the market in the US with a "black box" warning on the label (Celebrex). COX-2 is ...