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By analyzing 516 mutated enzymes that acquired the ceftazidime-hydrolyzing activity, we found twelve positions with single amino acid substitutions (altogether twenty-nine different substitutions), co-localized at the active-site pocket area. The ...
In a cohort study by Romano and colleagues, 128 penicillin-allergic patients (those who sustained anaphylactic shock or urticaria) underwent skin testing with cephalosporins (cephalotin, cefamandole, cefuroxime, ceftazidime, ceftriaxone, and cefotaxime).